I-alum ye-UCF kunye nabaphandi abaninzi basebenzisa i-nanotechnology ukuphuhlisa le arhente yokucoca, enokumelana neentsholongwane ezisixhenxe ukuya kwiintsuku ze-7.
Abaphandi be-UCF baye baphuhlisa isibulali-ntsholongwane esekwe kwi-nanoparticle esinokuthi ngokuqhubekayo sibulale iintsholongwane emhlabeni ukuya kuthi ga kwiintsuku ezisi-7-oku kufunyaniswayo kunokuba sisixhobo esinamandla ngokuchasene ne-COVID-19 kunye nezinye iintsholongwane ezikhulayo ze-pathogenic.
Uphando lupapashwe kule veki kwiphephancwadi i-ACS Nano ye-American Chemical Society yiqela leengcali ezininzi zentsholongwane kunye neengcali zobunjineli ezivela kwiyunivesiti kunye nentloko yenkampani yezobuchwepheshe e-Orlando.
UChristina Drake '07PhD, umseki weKismet Technologies, waphefumlelwa luhambo oluya kwivenkile ethengisa ukutya ekuqaleni kobhubhane kwaye wavelisa isibulali ntsholongwane. Apho, wabona umsebenzi etshiza isibulala-ntsholongwane kumqheba wefriji waza ngoko nangoko wasisula isitshizi.
“Ekuqaleni umbono wam yayikukuphuhlisa isibulali-ntsholongwane esisebenza ngokukhawuleza,” utshilo, “kodwa siye sathetha nabathengi abanjengoogqirha kunye noogqirha bamazinyo ukuze baqonde ukuba sesiphi isibulali-ntsholongwane abasifuna ngokwenene. Eyona nto ibalulekileyo kubo Yinto ehlala ixesha elide, izakuqhubeka nokubulala iintsholongwane kwiindawo eziphezulu zonxibelelwano ezifana nezibambo zocango kunye nomgangatho ixesha elide emva kokufakwa kwesicelo. ”
UDrake usebenza noSudipta Seal, injineli yezixhobo ze-UCF kunye nengcali ye-nanoscience, kunye noGriff Parks, ugqirha wentsholongwane egazini, igosa lophando elinxulumene neSikolo sezoNyango, kunye nomphathi weSikolo saseBurnett seSayensi yeBiomedical. Ngenkxaso-mali evela kwiSiseko seSayensi seSizwe, iKismet Tech, kunye neFlorida High-Tech Corridor, abaphandi baye benza i-nanoparticle yobunjineli bokubulala iintsholongwane.
Isithako saso esisebenzayo yi-nanostructure eyenziwe ngobunjineli ebizwa ngokuba yi-cerium oxide, eyaziwa ngokuba yi-antioxidant evuselelayo. I-Cerium oxide nanoparticles iguqulwa ngexabiso elincinci lesilivere ukuze isebenze ngakumbi kwii-pathogens.
“Isebenza kuzo zombini iikhemistri nakoomatshini,” utshilo uSeal, obefunda i-nanotechnology ngaphezulu kweminyaka engama-20. I-Nanoparticles ikhupha ii-electron ukuze i-oxidize intsholongwane kwaye iyenze ingasebenzi. Ngoomatshini, bazincamathela kwintsholongwane kwaye bagqabhuke umphezulu, njengokugqabhuka kwebhaluni. ”
Uninzi lokusula iintsholongwane okanye izitshizi ziyakubulala iintsholongwane kumphezulu kwimizuzu emithathu ukuya kwemithandathu emva kokusetyenziswa, kodwa akukho siphumo sishiyekileyo. Oku kuthetha ukuba umphezulu kufuneka wosulwe ngokuphindaphindiweyo ukuwugcina ucocekile ukunqanda usulelo ngeentsholongwane ezininzi ezifana ne-COVID-19. Ukuqulunqwa kwe-nanoparticle kugcina amandla ayo okungasebenzi kakuhle i-microorganisms kwaye iyaqhubeka nokutshabalalisa i-disinfecting ebusweni ukuya kwiintsuku ze-7 emva kwesicelo esisodwa.
“Esi sibulali ntsholongwane sibonisa umsebenzi omkhulu wokubulala iintsholongwane ngokuchasene neentsholongwane ezisixhenxe ezahlukeneyo,” utshilo uParks, onelabhoratri enoxanduva lokuvavanya ukuchasana kwefomula kwintsholongwane “isichazi-magama”. “Ayibonisi kuphela iipropathi ezichasene neentsholongwane ezichasene ne-coronavirus kunye neerhinoviruses, kodwa ikwangqina ukuba iyasebenza ngokuchasene neentlobo zezinye iintsholongwane ezinezakhiwo ezahlukeneyo kunye nobunzima. Siyathemba ukuba ngobu buchule bumangalisayo bokubulala, esi sibulali ntsholongwane siya kuba sisixhobo esisebenzayo ngokuchasene nezinye iintsholongwane ezikhulayo. ”
Iingcali zenzululwazi zikholelwa ukuba esi sisombululo siya kuba nempembelelo enkulu kwindawo yokunakekelwa kwempilo, ngakumbi ukunciphisa iziganeko zezifo ezifunyenwe esibhedlele, ezifana ne-methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa kunye neClostridium difficile—— Zichaphazela ngaphezu kwesinye kwi-30 izigulana ezingeniswe kwizibhedlele zaseMelika.
Ngokungafaniyo nezibulala-ntsholongwane ezininzi zorhwebo, le fomyula ayinayo imichiza eyingozi, ebonisa ukuba ikhuselekile ukuyisebenzisa nakweyiphi na indawo. Ngokweemfuno ze-Arhente yokuKhuselwa kokusiNgqongileyo yase-US, iimvavanyo zokulawula ulusu kunye nokucaphuka kweeseli zamehlo azibonisi ziphumo eziyingozi.
“Uninzi lwezixhobo zokubulala iintsholongwane zasekhaya ezikhoyo ngoku zinemichiza eyingozi emzimbeni emva kokuvezwa okuphindaphindiweyo,” utshilo uDrake. "Imveliso yethu esekelwe kwi-nanoparticle iya kuba nenqanaba eliphezulu lokhuseleko, eliya kudlala indima ebalulekileyo ekunciphiseni ukuchaswa kwabantu ngokubanzi kwiikhemikhali."
Uphando olongezelelekileyo luyafuneka phambi kokuba iimveliso zingene kwimarike, yiyo loo nto inqanaba elilandelayo lophando liya kujolisa ekusebenzeni kwezibulali ntsholongwane kwizicelo ezisebenzayo ngaphandle kwelabhoratri. Lo msebenzi uya kufunda ukuba izibulala-ntsholongwane zichatshazelwa njani zizinto zangaphandle ezifana nobushushu okanye ukukhanya kwelanga. Iqela likwiingxoxo nothungelwano lwesibhedlele sasekuhlaleni ukuvavanya imveliso kwiindawo zabo.
“Sikwavavanya uphuhliso lwefilimu esisigxina ukubona ukuba singakwazi na ukuvala kwaye sitywine imigangatho yesibhedlele okanye izibambo zocango, iindawo ezifuna ukubulawa iintsholongwane, okanye iindawo zokunxibelelana ngokuqhubekayo,” utshilo uDrake.
U-Seal wajoyina i-UCF yeSebe lezeNzululwazi kunye nobuNjineli ngo-1997, eyinxalenye yeSikolo se-UCF sobuNjineli kunye neNzululwazi yeKhompyutha. Ukufakelwa kwamalungu omzimba. Ungumlawuli wangaphambili we-UCF Nano Science and Technology Centre kunye ne-Advanced Materials Processing and Analysis Centre. Ufumene i-PhD kubunjineli bezinto zokwakha kwiYunivesithi yaseWisconsin, enomntwana omncinci kwi-biochemistry, kwaye ungumphandi we-postdoctoral kwi-Lawrence Berkeley National Laboratory kwiYunivesithi yaseCalifornia, eBerkeley.
Emva kokusebenza kwi-Wake Forest School of Medicine iminyaka eyi-20, iiParks zafika kwi-UCF kwi-2014, apho wayesebenza njengoprofesa kunye nentloko yeSebe leMicrobiology kunye ne-Immunology. Wafumana isidanga sePh.D. kwi-biochemistry evela kwiYunivesithi yaseWisconsin kwaye ungumphandi we-American Cancer Society kwiYunivesithi yaseNorthwestern.
Uphononongo lubhalwe ngokubambisana nguCandace Fox, umphandi we-postdoctoral kwiSikolo seMithi, kunye noCraig Neal ovela kwiSikolo soBunjineli kunye neNzululwazi yeKhompyutha. I-Tamil Sakthivel, u-Udit Kumar, kunye no-Yifei Fu, abafundi abaphumelele kwiSikolo soBunjineli kunye neNzululwazi yeKhompyutha, nabo bangababhali abasebenzisanayo.
Ixesha lokuposa: Sep-04-2021