Abaphandi kwiDyunivesithi yaseCentral Florida baphuhlise isibulala-ntsholongwane esekwe kwi-nanoparticle esinokuthi ngokuqhubekayo sibulale iintsholongwane kumphezulu ukuya kuthi ga kwiintsuku ezisi-7-ukufunyanwa okunokuba sisixhobo esinamandla ngokuchasene ne-COVID-19 kunye nezinye iintsholongwane ze-pathogenic ezivelayo.
Uphando lupapashwe kule veki kwiphephancwadi i-ACS Nano ye-American Chemical Society yiqela leengcali ezininzi zentsholongwane kunye neengcali zobunjineli ezivela kwiyunivesiti kunye nentloko yenkampani yezobuchwepheshe e-Orlando.
Ngeentsuku zokuqala zobhubhane, uChristina Drake, umfundi wase-UCF kunye nomseki weKismet Technologies, waphefumlelwa emva kohambo oluya kwivenkile ethengisa ukutya ukuze aphuhlise amayeza okubulala iintsholongwane. Apho, wabona umsebenzi etshiza isibulala-ntsholongwane kumqheba wefriji waza ngoko nangoko wasisula isitshizi.
“Ekuqaleni umbono wam yayikukuvelisa isibulali-ntsholongwane esisebenza ngokukhawuleza,” utshilo, “kodwa sathetha nabathengi—njengoogqirha noogqirha bamazinyo—ukufumanisa ukuba sesiphi isibulali-ntsholongwane abasifuna ngokwenene. Kubo Eyona nto ibalulekileyo yinto ehlala ihleli. Iza kuqhubeka nokubulala iintsholongwane kwiindawo eziphezulu zoqhagamshelwano ezifana nezibambo zeminyango kunye nemigangatho ixesha elide emva kokufakwa kwesicelo. ”
UDrake usebenzisane noGqr. Sudipta Seal, injineli yezinto ze-UCF kunye nengcali ye-nanoscience, kunye noGqr. Griff Parks, i-virologist, i-Dean yophando yeSikolo sezoNyango, kunye ne-Dean ye-Burnett School of Biomedical Sciences. Ngenkxaso-mali evela kwiSiseko seSayensi seSizwe, iKismet Tech, kunye neFlorida High-Tech Corridor, abaphandi benza i-nanoparticle yobunjineli bokubulala iintsholongwane.
Isithako saso esisebenzayo yi-nanostructure eyenziwe ngobunjineli ebizwa ngokuba yi-cerium oxide, eyaziwa ngokuba yi-antioxidant evuselelayo. I-Cerium oxide nanoparticles iguqulwa ngexabiso elincinci lesilivere ukuze isebenze ngakumbi kwii-pathogens.
USeal, obefunda i-nanotechnology ngaphezu kweminyaka engama-20 uthi: “Isebenza kumachiza nakoomatshini. I-Nanoparticles ikhupha ii-electron ukuze i-oxidize intsholongwane kwaye iyenze ingasebenzi. Ngoomatshini, bazincamathela kwintsholongwane kwaye bagqabhuke umphezulu njengebhaluni eqhumayo. ”
Uninzi lokusula iintsholongwane okanye izitshizi ziyakubulala iintsholongwane kumphezulu kwimizuzu emithathu ukuya kwemithandathu emva kokusetyenziswa, kodwa akukho siphumo sishiyekileyo. Oku kuthetha ukuba umphezulu kufuneka wosulwe ngokuphindaphindiweyo ukuwugcina ucocekile ukunqanda usulelo ngeentsholongwane ezininzi ezifana ne-COVID-19. Ukuqulunqwa kwe-nanoparticle kugcina amandla ayo okungasebenzi kakuhle i-microorganisms kwaye iyaqhubeka nokutshabalalisa i-disinfecting ebusweni ukuya kwiintsuku ze-7 emva kwesicelo esisodwa.
“Amayeza okubulala iintsholongwane abonisa umsebenzi omkhulu wokulwa neentsholongwane ezichasene neentsholongwane ezisixhenxe,” utshilo uParks, kwaye ilabhoratri yakhe inoxanduva lokuvavanya ukuchasana kwefomula kwintsholongwane “isichazi-magama”. “Ayibonisanga kuphela iipropathi ezichasene neentsholongwane ezichasene ne-coronavirus kunye neerhinoviruses, kodwa ikwangqineke isebenza ngokuchasene nezinye iintsholongwane ezinezakhiwo ezahlukeneyo kunye nobunzima. Siyathemba ukuba ngobu buchule bumangalisayo bokubulala, esi sibulali ntsholongwane siya kuba sisixhobo esisebenzayo ngokuchasene nezinye iintsholongwane ezisakhulayo. ”
Iingcali zenzululwazi zikholelwa ukuba esi sisombululo siya kuba nempembelelo enkulu kwindawo yokunakekelwa kwempilo, ngakumbi ukunciphisa iziganeko zezifo ezifunyenwe esibhedlele-ezifana ne-methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa kunye neClostridium difficile -Ezi ziya kubangela izifo ezichaphazela ngaphezu isinye kwisithathu sezigulana ezingeniswe kwizibhedlele zase-US.
Ngokungafaniyo nezibulala-ntsholongwane ezininzi zorhwebo, le fomyula ayinayo imichiza eyingozi, ebonisa ukuba ikhuselekile ukuyisebenzisa nakweyiphi na indawo. Ngokweemfuno ze-Arhente yokuKhuselwa kokusiNgqongileyo yase-US, iimvavanyo zokulawula ulusu kunye nokucaphuka kweeseli zamehlo azibonisi ziphumo eziyingozi.
“Uninzi lwezixhobo zokubulala iintsholongwane zasekhaya ezikhoyo ngoku zinemichiza eyingozi emzimbeni emva kokuvezwa okuphindaphindiweyo,” utshilo uDrake. "Imveliso yethu esekelwe kwi-nanoparticle iya kuba nenqanaba eliphezulu lokhuseleko, eliya kudlala indima ebalulekileyo ekunciphiseni ukuchaswa kwabantu ngokubanzi kwiikhemikhali."
Uphando olongezelelekileyo luyafuneka phambi kokuba iimveliso zingene kwimarike, yiyo loo nto inqanaba elilandelayo lophando liya kujolisa ekusebenzeni kwezibulali ntsholongwane kwizicelo ezisebenzayo ngaphandle kwelabhoratri. Lo msebenzi uya kufunda ukuba izibulala-ntsholongwane zichatshazelwa njani zizinto zangaphandle ezifana nobushushu okanye ukukhanya kwelanga. Iqela likwiingxoxo nothungelwano lwesibhedlele sasekuhlaleni ukuvavanya imveliso kwiindawo zabo.
UDrake wongeze wathi: “Sikwavavanya uphuhliso lwefilimu esisigxina ukubona ukuba singagquma kwaye sitywine imigangatho yesibhedlele okanye imiqheba yeengcango, iindawo ezifuna ukubulawa iintsholongwane, okanye iindawo ezisebenza ngokuqhubekayo nangokuqhubekayo.
U-Seal wajoyina i-UCF yeSebe lezeNzululwazi kunye nobuNjineli ngo-1997, eyinxalenye yeSikolo se-UCF sobuNjineli kunye neNzululwazi yeKhompyutha. Usebenza kwisikolo sezonyango kwaye ulilungu leqela le-UCF le-prosthetic Biionix. Ungumlawuli wangaphambili we-UCF Nano Science and Technology Centre kunye ne-Advanced Materials Processing and Analysis Centre. Ufumene i-PhD kubunjineli bezinto zokwakha kwiYunivesithi yaseWisconsin, enomntwana omncinci kwi-biochemistry, kwaye ungumphandi we-postdoctoral kwi-Lawrence Berkeley National Laboratory kwiYunivesithi yaseCalifornia, eBerkeley.
Emva kokusebenza kwi-Wake Forest School of Medicine iminyaka eyi-20, iiParks zafika kwi-UCF kwi-2014, apho wayesebenza njengoprofesa kunye nentloko yeSebe leMicrobiology kunye ne-Immunology. Wafumana isidanga sePh.D. kwi-biochemistry evela kwiYunivesithi yaseWisconsin kwaye ungumphandi we-American Cancer Society kwiYunivesithi yaseNorthwestern.
Uphando lubhalelwe nguCandace Fox, umphandi we-postdoctoral ovela kwi-UCF School of Medicine, uCraig Neal ovela kwiSikolo se-UCF sobuNjineli kunye neSayensi yeKhompyutha, kunye nabafundi abaphumelele iTamil Sakthivel, u-Udit Kumar, kunye noYifei Fu kwiSikolo se-UCF sobuNjineli kunye neSayensi yeKhompyutha. .
Izixhobo ezibonelelwa yiYunivesithi yaseCentral Florida. Umsebenzi wokuqala nguChristine Senior. Qaphela: Umxholo ungahlelwa ngokwesitayile nobude.
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Ixesha lokuposa: Sep-10-2021